BookMohmmad Younus Wani, Manzoor Ahmad Malik.
Summary: This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes mechanism of action and toxicity issues and, in closing, outlines future research directions.
Contents:
Chapter 1. Cancer
Chapter 2. Types of cancer
Chapter 3. Classification
Chapter 4. Cancer or tumor nomenclature
Chapter 5. Heterogeneity
Chapter 6. Invasion and metastasis
Chapter 7. How cancer arises?
Chapter 8. Epidemiology
Chapter 9. Economic burden
Chapter 10. Treatment modalities
Chapter 11. Chemotherapy
Chapter 12. Properties of metals and metal complexes
Chapter 13. Platinum based anticancer agents
Chapter 14. Chemistry of cisplatin
Chapter 15. Mechanism of action of platinum drugs
Chapter 16. Non-platinum anticancer agents
Chapter 17. Chemistry of gold
Chapter 18. Gold and its complexes in medicine
Chapter 19. Auranofin and its analogues
Chapter 20. Classes of gold complexes
Chapter 21. Mechanisms of action of anticancer gold complexes
Chapter 22. Perspectives.